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胎盘发生过程中的细胞凋亡

高飞, 傅国强, 丁峰, 刘以训

中科院动物研究所生殖生物学国家重点实验室.北京 100080

摘要

细胞凋亡是一种正常的生理现象。在胚泡着床过程中,伴随有大量细胞凋亡。研究表明,胎盘发生过程中的细胞凋亡,对调控子宫内膜基质细胞的蜕膜化和滋养层细胞的浸润以形成胎盘具有重要意义;另外,由Fas/FasL系统介导的细胞凋亡可能与母体对胎儿的免疫耐受性有关。该文主要评述细胞凋亡的一般通路以及胎盘发生过程中细胞凋亡的调控。

关键词： 凋亡; 胎盘发生; 免疫耐受; Fas/FasL

Apoptosis during placentation

Gao Fei, Fu Guoqiang, Ding Feng, Liu Yixun

State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences.Beijing 100080

Abstract

Apoptosis is a normal physiological phenomenon. During the process of implantation, there are a large number of cells at the implantation site undergoing apoptosis, which has been suggested to play an important role in the regulation of endometrium decidulization and trophoblast invasion. Apoptosis mediated by Fas/FasL system may also be associated with maternal immunotolerance to the fetus. In this review, the common pathway of apoptosis and the regulation in the placenta are described.

Key words: Apoptosis;Placentation;Immunotole rance;Fas/ FasL

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引用本文：

高飞, 傅国强, 丁峰, 刘以训. 胎盘发生过程中的细胞凋亡[J]. 生理学报 2001; 53 (6): .

Gao Fei, Fu Guoqiang, Ding Feng, Liu Yixun. Apoptosis during placentation. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).