过刊浏览

NO在CCK-8减轻肿瘤坏死因子诱导兔肺动脉反应性变化中的作用

孟爱宏, 凌亦凌, 王殿华, 谷振勇, 李淑瑾, 朱铁年

河北医科大学病理生理教研室.河北,石家庄 050017

摘要

为探讨八肽胆囊收缩素(CCK-8)缓解内毒素休克时肺动脉高压的作用机制,应用离体血管环张力测定技术及一氧化氮合酶(NOS)检测方法,观察了一氧化氮(NO)在CCK-8减轻肿瘤坏死因子-#alpha#(tumor necrosis factor-alpha,TNF-#alpha#)的抑制肺动脉内皮依赖性舒张反应中的作用。结果提示,CCK-8可逆转TNF-#alpha#对内皮依赖性舒张反应的抑制作用,此作用可能与NO有关。

关键词： 缩胆囊素; 肿瘤坏死因子; 一氧化氮; 肺动脉; 血管反应性

Role of nitric oxide in cholecystokinin-octapeptide alleviation of tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity

Meng Aihong, Ling Yiling, Wang Dianhua, Gu Zhenyong, Li Shujin, Zhu Tienian

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

Results suggest that CCK-8 prevents TNF-#alpha# induced impairment in endothelium-dependent relaxation response, and the effects of both CCK-8 and TNF-#alpha# are related to NO.

Key words: Cholecystokinixr octapeptide;Tumor necrosis factor alpha;Nitric oxide;Pul monary;Vascular reactivity

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

孟爱宏, 凌亦凌, 王殿华, 谷振勇, 李淑瑾, 朱铁年. NO在CCK-8减轻肿瘤坏死因子诱导兔肺动脉反应性变化中的作用[J]. 生理学报 2001; 53 (6): .

Meng Aihong, Ling Yiling, Wang Dianhua, Gu Zhenyong, Li Shujin, Zhu Tienian. Role of nitric oxide in cholecystokinin-octapeptide alleviation of tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).