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G#alpha#q/11介导的细胞信号转导在两肾一夹肾性高血压大鼠主动脉中的变化

邢东琦, 白桦, 马铁民, 吴立玲

北京大学医学部生理与病理生理系.北京 100083；北京邮电总医院心内科.北京 100032

摘要

肾素依赖性高血压能引起大鼠主动脉G#alpha#q/11介导的细胞信号转导系统激活,并参与高血压的发生和发展。

关键词： 两肾一夹肾性高血压; Gαq/11亚单位; 磷脂酶C; 细胞外信号调节激酶1/2

Changes in G#alpha#q/11-mediated signal transduction pathway in the aorta of two kidney one clip hypertensive rats

Xing Dongqi, Bai Hua, Ma Tiemin, Wu Liling

Department of Physiology and Pathophysiology,Peking University Health Science Center.Beijing 100083；China

Abstract

The results indicate that G#alpha#q/11-mediated signal transduction pathway of the aorta is activated in 2K1C hypertension, and may contribute to the initiation and maintenance of renal hypertension.

Key words: Renal hypertension;Gaq/11 protein;Phospholipase C;Extracellular signal-regulated kinase 1/2

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引用本文：

邢东琦, 白桦, 马铁民, 吴立玲. G#alpha#q/11介导的细胞信号转导在两肾一夹肾性高血压大鼠主动脉中的变化[J]. 生理学报 2001; 53 (6): .

Xing Dongqi, Bai Hua, Ma Tiemin, Wu Liling. Changes in G#alpha#q/11-mediated signal transduction pathway in the aorta of two kidney one clip hypertensive rats. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).