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脂多糖直接损伤血管内皮细胞后内皮细胞膜脂的修饰

王翔, 蔡绍皙, 罗向东, 王裴, 罗勤, 梁光萍, 杨宗城

重庆大学生物工程学院,国家教育部生物力学及生物流变学开放实验室.重庆 400044；第三军医大学西南医院烧伤研究所.重庆 400038

摘要

LPS可直接激活血管内皮细胞膜磷脂代谢,诱导HUVEC膜磷脂的修饰,提示LPS直接损伤血管内皮细胞HUVEC的途径可能与膜结构组成及膜脂代谢有关。

关键词： 脂多糖; 直接损伤; 内皮细胞; 膜磷脂修饰

Modification of membrane lipid of human umbilical vein endothelial cells after direct lipopolysaccharide injury

Wang Xiang, Cai Shaoxi, Luo Xiangdong, Wang Pei, Luo Qin, Liang Guangping, Yang Zongcheng

Bioengineering College of Chongqing University,The Open Laboratory for Biomechanics and Biorheology Under the Ministry of Education.Chongqing 400044；China

Abstract

Results indicate that LPS directly activates the metabolism of HUVEC membrane lipid and induces the modification of HUVEC membrane phospholipid, which implies that the mechanism of the impairment of HUVECs by LPS may be related to the membrane structure of HUVECs and the metabolism of HUVEC membrane lipid.

Key words: Lipopolysaccharide(LPS);Direct damage;Human umbilical vein endothelial cell(HUVEC);Modification of membrane lipid

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引用本文：

王翔, 蔡绍皙, 罗向东, 王裴, 罗勤, 梁光萍, 杨宗城. 脂多糖直接损伤血管内皮细胞后内皮细胞膜脂的修饰[J]. 生理学报 2001; 53 (6): .

Wang Xiang, Cai Shaoxi, Luo Xiangdong, Wang Pei, Luo Qin, Liang Guangping, Yang Zongcheng. Modification of membrane lipid of human umbilical vein endothelial cells after direct lipopolysaccharide injury. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).