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中枢精氨酸加压素在大鼠促肾上腺皮质激素释放激素引起发热机制中的作用

王华东, 王彦平, 胡巢凤, 戚仁斌, 严玉霞, 陆大祥, 李楚杰

暨南大学医学院病理生理教研室.广东,广州 510632；暨南大学医学院生化教研室.广东,广州 510632

摘要

实验对大鼠进行第三脑室和脑腹中隔区插管,用数字体温计测量大鼠的结肠温度,用放射免疫分析法测定脑中隔区精氨酸加压素(arginine vasopressin,AVP)含量,观察脑中隔区AVP在大鼠促肾上腺皮质激素释放激素(corticotrophin releasing hormone,CRH)性发热机制中的作用。结果提示:发热时CRH是引起脑腹中隔区AVP释放的因素之一,脑腹中隔区内源性AVP抑制中枢注射CRH引起的体温升高。

关键词： 促肾上腺皮质激素释放激素; 精氨酸加压素; 发热; 体温调节

The role of central arginine vasopressin in corticotropin releasing hormone-induced fever in rats

Wang Huadong, Wang Yanping, Hu Chaofeng, Qi Renbin, Yan Yuxia, Lu Daxiang, Li Chujie

Departments of Pathophysiology,Medical College of Jinan University.Guangzhou 510632,Guangdong；China

Abstract

The purpose of the present study was to investigate the role of central arginine vasopressin (AVP) in corticotropin releasing hormone (CRH)-induced fever in the rat. Guide cannulae were inserted into the third ventricle and placed over the ventral septal area (VSA). The content of arginine vasopressin in the VSA of the brain was determined by radioimmunoassay. Colon temperature was monitored in lightly restrained rats by insertion of a catheter-mounted thermistor probe 5 cm in the rectum.

Key words: Corticotrophin releasing hormone;Arginine vasopressin;Fever;Thermoregulation

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引用本文：

王华东, 王彦平, 胡巢凤, 戚仁斌, 严玉霞, 陆大祥, 李楚杰. 中枢精氨酸加压素在大鼠促肾上腺皮质激素释放激素引起发热机制中的作用[J]. 生理学报 2001; 53 (6): .

Wang Huadong, Wang Yanping, Hu Chaofeng, Qi Renbin, Yan Yuxia, Lu Daxiang, Li Chujie. The role of central arginine vasopressin in corticotropin releasing hormone-induced fever in rats. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).