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17#beta#-雌二醇下调血管平滑肌内皮素A型受体的表达

王庭槐, 谈智, 刘培庆, 鲁伟, 杨丹, 潘敬运

中山医科大学生理教研室.广东,广州 510089

摘要

ET-1促VSMCs增殖的效应主要是由ET_(A)R介导的,雌激素能通过下调ET_(A)R来抑制ET-1对VSMCs促增殖的作用和血管对ET-1的反应,且此作用与雌激素受体有关。

关键词： 雌激素; 雌激素受体; 血管平滑肌细胞; 内皮素; 内皮素受体

Down-regulation of ET_(A) receptor of vascular smooth muscle cells by 17#beta#-estradiol

Wang Tinghuai, Tan Zhi, Liu Peiqing, Lu Wei, Yang Dan, Pan Jingyun

Department of Physiology,Sun Yat-sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The results demonstrate that proliferation of VSMCs stimulated by ET-1 was mainly mediated through ET_(A) receptor. Due to the down-regulation of ET_(A) receptor and mediation of estrogen receptor, 17#beta#-estradiol inhibits the ET-1-induced proliferation of VSMCs and decreases the vascular reactivity of ovariectomized rats.

Key words: Estrogen;Estrogen receptor;VSMCs;Endothelin;Endothelin receptor

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引用本文：

王庭槐, 谈智, 刘培庆, 鲁伟, 杨丹, 潘敬运. 17#beta#-雌二醇下调血管平滑肌内皮素A型受体的表达[J]. 生理学报 2001; 53 (5): .

Wang Tinghuai, Tan Zhi, Liu Peiqing, Lu Wei, Yang Dan, Pan Jingyun. Down-regulation of ET_(A) receptor of vascular smooth muscle cells by 17#beta#-estradiol. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).