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血管紧张素-(1-7)对大鼠血管平滑肌细胞PKC和ERK1/2的抑制作用

钟健, 祝之明, 杨永健

第三军医大学大坪医院高血压内分泌科,重庆市高血压病研究所.重庆 400042

摘要

Ang-(1-7)能明显抑制基础和AngⅡ刺激下的VSMCs PKC-#zeta#和ERK1/2蛋白表达(P<0.01或P<0.05),减少~(3)H-TdR和~(3)H-Leu掺入量(P<0.01或P<0.05)。

关键词： 血管紧张素-(1-7); 蛋白激酶C; 胞外调节蛋白激酶; 血管平滑肌细胞

Inhibition of PKC and ERK1/2 in cultured rat vascular smooth muscle cells by angiotensin-(1-7)

Zhong Jian, Zhu Zhiming, Yang Yongjian

Department of Hypertension and Endocrinology and Chongqing Institute of Hypertension,Daping Hospital,The Third Military Medical University.Chongqing 400042

Abstract

Ang II increased VSMC DNA and protein synthesis, and promoted protein expression of PKC-#zeta# and ERK1/2. In contrast, Ang-(1-7) not only inhibited PKC-#zeta# and ERK1/2 protein content, but also decreased Ang II mediated VSMC hyperplasia, as compared with the controls (P<0.01 or P<0.05).

Key words: Angiotensirr(1-7);Protein kinase C;Extracellular regulated protein kinases;Vascular smooth muscle cells

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引用本文：

钟健, 祝之明, 杨永健. 血管紧张素-(1-7)对大鼠血管平滑肌细胞PKC和ERK1/2的抑制作用[J]. 生理学报 2001; 53 (5): .

Zhong Jian, Zhu Zhiming, Yang Yongjian. Inhibition of PKC and ERK1/2 in cultured rat vascular smooth muscle cells by angiotensin-(1-7). Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).