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帕金森病模型大鼠脑内多巴胺与铁含量的关系

姜宏, 陈文芳, 谢俊霞

青岛大学医学院生理教研室.山东,青岛 266021

摘要

6-OHDA可导致CPu DA释放量及含量减少,此过程有铁的参与。由于铁可导致DA神经元死亡,因此铁含量的增加可能是DA含量减少的原因之一,甲磺酸去铁胺具有保护DA神经元的作用。

关键词： 帕金森病模型鼠; 铁; 甲磺酸去铁胺; 黑质; 纹状体; 多巴胺

Relationship between dopamine and iron contents in the brain of Parkinsonian rats

Jiang Hong, Chen Wenfang, Xie Junxia

Medical School of Qingdao University.Qingdao 266021,Shandong

Abstract

The results strongly suggest that 6-OHDA reduces the DA release from CPu, in which iron plays an important role. Elevation of iron content in SN is one of the mechanisms responsible for the reduction of DA content. Desferrioxamine mesylate may exert a protective action on dopaminergic neurons.

Key words: Parkinsonian rats;Iron;Desferrioxamine mesylate;Substantia nigra;Caudate putamen;Dopamine

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引用本文：

姜宏, 陈文芳, 谢俊霞. 帕金森病模型大鼠脑内多巴胺与铁含量的关系[J]. 生理学报 2001; 53 (5): .

Jiang Hong, Chen Wenfang, Xie Junxia. Relationship between dopamine and iron contents in the brain of Parkinsonian rats. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).