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肾上腺髓质素和降钙素基因相关肽受体在血管平滑肌细胞的脱敏--受体活性修饰蛋白的作用

齐永芬, 薛琳, 柴三葆, 石彦荣, 庞永正, 唐朝枢

北京大学第一医院心血管病研究所.北京 100034

摘要

在离体培养的大鼠VSMCs,ADM受体不脱敏而CGRP受体对预先用ADM和CGRP处理后的激动剂的第二次刺激都脱敏,表明ADM和CGRP的脱敏现象不一致。

关键词： 肾上腺髓质素; 降钙素基因相关肽; 血管平滑肌细胞; 脱敏; 受体活性修饰蛋白

Desensitization of adrenomedullin and calcitonin gene-related peptide receptors in vascular smooth muscle cells--Effects of receptor activity-modifying protein

Qi Yongfen, Xue Lin, Chai Sanbao, Shi Yanrong, Pang Yongzheng, Tang Chaoshu

Institute of Cardiovascular Research,The First Hospital,Peking University.Beijing 100034

Abstract

Results indicate that ADM receptors do not desensitize in VSMCs in contrast to CGRP-receptors, which are desensitized by pre-exposure to ADM or CGRP. These data also suggest that the desensitization phenomenon of ADM is different from that of CGRP.

Key words: Adre nome dullin;Calcitonin gene-related peptide;Vascular smooth muscle cells;Densensitization;Receptor activity modifying protein

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引用本文：

齐永芬, 薛琳, 柴三葆, 石彦荣, 庞永正, 唐朝枢. 肾上腺髓质素和降钙素基因相关肽受体在血管平滑肌细胞的脱敏--受体活性修饰蛋白的作用[J]. 生理学报 2001; 53 (5): .

Qi Yongfen, Xue Lin, Chai Sanbao, Shi Yanrong, Pang Yongzheng, Tang Chaoshu. Desensitization of adrenomedullin and calcitonin gene-related peptide receptors in vascular smooth muscle cells--Effects of receptor activity-modifying protein. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).