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大鼠脑线粒体NOS及L-Arg转运的生化特性

曹军, 王蕾, 赵保路, 陈清棠, 齐永芬, 唐朝枢

北京大学第一医院心血管研究所.北京 100034；北京大学第一医院神经研究中心.北京 100034；中科院生物物理研究所.北京 100101

摘要

正常大鼠Mt膜上存在L-Arg转运体,该转运体与细胞膜上Y~(+)型氨基酸转运体相一致;Mt NOS属eNOS. Mt L-Arg/NOS/NO系统是细胞NO产生的来源之一。

关键词： 线粒体; 一氧化氮; L精氨酸; 一氧化氮合酶; 脑

The biochemical properties of L-arginine/nitric oxide pathway in rat brain mitochondria

Cao Jun, Wang Lei, Zhao Baolu, Chen Qingtang, Qi Yongfen, Tang Chaoshu

Institute of Cardiovascular Diseases,The First Hospital,Peking University.Beijing 100034；China；Institute of Biophysics,Chinese Academy of Sciences.Beijing 100101

Abstract

Results suggest that the L-Arg transporters in MT membrane of normal rat brain were similar with Y~(+) type amino acid transporters in cellullar membrane. Furthermore the NOS of mitochondria belongs to eNOS, whereas the L-Arg/NOS/NO system may be a source of NO.

Key words: Mitochondria;Nitric oxide;Larginie transport;Nitric oxide synthase ;

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引用本文：

曹军, 王蕾, 赵保路, 陈清棠, 齐永芬, 唐朝枢. 大鼠脑线粒体NOS及L-Arg转运的生化特性[J]. 生理学报 2001; 53 (4): .

Cao Jun, Wang Lei, Zhao Baolu, Chen Qingtang, Qi Yongfen, Tang Chaoshu. The biochemical properties of L-arginine/nitric oxide pathway in rat brain mitochondria. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).