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血小板生成素诱导胎肝CD34~(+)造血干/祖细胞增殖分化与周期蛋白表达的关系

马东初, 金伯泉, 孙英慧, 常奎忠, 戴兵, 初俊杰, 刘亚革

沈阳军区总医院医学实验科.辽宁,沈阳 110015；第四军医大学免疫教研室.陕西,西安 710032

摘要

(1)TPO通过上调周期蛋白B1和在所有细胞周期时限上调周期蛋白D1和D3表达,促进巨核细胞祖细胞的增殖分化;(2)周期蛋白B1在G2+M期的持续高水平和周期蛋白D1和D3在G2+M期的水平下降,可能导致胎肝源巨核细胞内有丝分裂延迟或阻滞。

关键词： 周期蛋白; 血小板生成素; CD34+细胞; 巨核细胞

Changes in cyclin expression during proliferation and differentiation of CD34~(+) cells derived from fetal liver induced by thrombopoietin

Ma Dongchu, Jin Boquan, Sun Yinghui, Chang Kuizhong, Dai Bing, Chu Junjie, Liu Yage

Northern Hospital.Shenyang 110015,Liaoning；China

Abstract

These data suggest that (1) TPO induced proliferation and differentiation of FL derived CD34~(+) cells through upregulation of cyclin B1 in G2+M phases and cyclins D1 and D3 in all phases of cell cycle, and (2) Continuing high level of cyclin B1 and decreases of cyclins D1 and cyclin D3 on MKs in G2+M phases may contribute to a retardation of MK endoreduplication.

Key words: Cyclins;Thrombopoietin;CD3~(4+)cells;Megakaiyocyte

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引用本文：

马东初, 金伯泉, 孙英慧, 常奎忠, 戴兵, 初俊杰, 刘亚革. 血小板生成素诱导胎肝CD34~(+)造血干/祖细胞增殖分化与周期蛋白表达的关系[J]. 生理学报 2001; 53 (4): .

Ma Dongchu, Jin Boquan, Sun Yinghui, Chang Kuizhong, Dai Bing, Chu Junjie, Liu Yage. Changes in cyclin expression during proliferation and differentiation of CD34~(+) cells derived from fetal liver induced by thrombopoietin. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).