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非洲爪蟾卵母细胞GABA_(B)和GABA_(C)受体介导的电流反应

杨青, 李之望, 魏劲波

武汉大学医学院生理教研室.湖北,武汉 430071；华中科技大学同济医学院实验医学研究中心.湖北,武汉 430030

摘要

在非洲爪蟾的卵母细胞上存在内源性GABA_(B)和GABA_(C)受体,GABA_(B)受体介导的为外向电流,而GABA_(C)受体介导的为内向电流。

关键词： 非洲爪蟾卵母细胞; GABAB受体; GABAC受体; baclofen; 2-hydroxysaclofen; I4AA; 双电极电压箝

Current responses mediated by endogenous GABA_(B) and GABA_(C) receptors in Xenopus oocytes

Yang Qing, Li Zhiwang, Wei Jingbo

Department of Physiology,Medical College of Wuhan University.Wuhan 430071,Hubei；China

Abstract

These results suggest that there exist endogenous GABA receptors, GABA_(B) receptors mediating a slow and sustained outward current and GABA_(C) receptors mediating an inward current in follicular Xenopus oocytes.

Key words: Xenopus oocytes;GABAB receptor;GABAc receptor;Bacl ofen;2- hydroxysacl ofen;14 AA;twoelectrode voltage-clamp recording

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引用本文：

杨青, 李之望, 魏劲波. 非洲爪蟾卵母细胞GABA_(B)和GABA_(C)受体介导的电流反应[J]. 生理学报 2001; 53 (4): .

Yang Qing, Li Zhiwang, Wei Jingbo. Current responses mediated by endogenous GABA_(B) and GABA_(C) receptors in Xenopus oocytes. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).