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心肌肥厚大鼠心肌细胞核三磷酸肌醇受体的特性

刘健, 何作云, 许蜀闽, 刘福玉, 王培勇

第三军医大学新桥医院心内科.重庆 400037；第三军医大学病理生理教研室.重庆 400038

摘要

大鼠心肌细胞核上存在IR_(3)R、CaM和PKC激动剂PMA,能显著抑制该受体与IP_(3)的结合(P<0.05);核外[Ca~(2+)]也能剂量依赖的抑制细胞核IP_(3)R与IP_(3)的结合。腹主动脉缩窄术后4周,大鼠心肌显著肥大,伴有明显的血流动力学异常,其心肌细胞核IP_(3)R的B_(max)和Kd与对照组比较分别增加1.217和2.149倍(P<0.01)。

关键词： 心肌肥厚; 细胞核; 肌醇1,4,5-三磷酸受体

Inositol 1, 4, 5-triphosphate receptors (IP_(3)Rs) in myocardial nuclei involved in pressure overload-induced hypertrophy of rat heart

Liu Jian, He Zuoyun, Xu Shumin, Liu Fuyu, Wang Peiyong

Department of Cardiology,Xinqiao Hospital,Third Medical University.Chongqing 400037；China

Abstract

The results suggest that IP_(3)Rs exist in myocardial nuclei and are down regulated by CaM, PMA and free Ca~(2+). The increase of the binding sites of IP_(3)Rs in the nuclear envelopes and the decrease of their affinity might play importment roles in the development of overload induction of cardiac hypertrophy.

Key words: Myocardial hypertrophy;Cell nucleus;Inositol 1 ,4 ,5-triphosphate receptors

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引用本文：

刘健, 何作云, 许蜀闽, 刘福玉, 王培勇. 心肌肥厚大鼠心肌细胞核三磷酸肌醇受体的特性[J]. 生理学报 2001; 53 (4): .

Liu Jian, He Zuoyun, Xu Shumin, Liu Fuyu, Wang Peiyong. Inositol 1, 4, 5-triphosphate receptors (IP_(3)Rs) in myocardial nuclei involved in pressure overload-induced hypertrophy of rat heart. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).