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人脑对不同频率穴位电刺激反应的功能性磁共振成像

金真, 张蔚婷, 罗非, 张奎伶, 张磊, 曾亚伟, 韩济生

北京解放军306医院磁共振室.北京 100101；北京大学神经科学研究所.北京 100083

摘要

利用功能性磁共振方法研究人脑对不同频率穴位体表电刺激(transcutaneous electric nerve stimulation,TENS)的反应。实验对11名志愿者进行了22次脑部功能性磁共振成像。成像过程中,每名志愿者分别接受了2和100Hz TENS刺激,刺激部位为左腿足三里和三阴交穴。结果为不同频率TENS都激活了初级和次级躯体感受区。频率特异性的激活信号出现在与运动相关的区域、丘脑、边缘系统和联络皮层。结果显示,在相同穴位给予不同频率的TENS可以在大脑引起不同的反应,提示2和100Hz TENS可能激活了不同的神经通路,这些神经通路分别在中枢神经系统起着不同的作用。

关键词： 磁共振; 功能性脑成像; 穴位体表电刺激; 针灸; 镇痛

Frequency-specific responses of human brain to peripheral transcutaneous electric nerve stimulation: a functional magnetic resonance imaging study

Jin Zhen, Zhang Weiting, Luo Fei, Zhang Kuiling, Zhang Lei, Zeng Yawei, Han Jisheng

Magnetic Resonance Imaging Unit,Hospital 306.Beijing 100101；China

Abstract

The purpose of the present investigation was to determine the responses of human brain to transcutaneous electric nerve stimulation (TENS) at different frequencies by functional magnetic resonance imaging (fMRI) examinations covering the whole brain of eleven healthy volunteers. Each subject received TENS at acupoints ST36 and SP6 of the left leg at the frequencies of 2 and 100 Hz. Frequency-specific responses were found in motor-related areas, thalamus, limbic system and associated cortex to stimulation of the two frequencies, while the primary somatosensory areas were activated by both. Therefore, it appears that 2 and 100 Hz TENS act through different neuro-pathways in the central nervous system.

Key words: fMRI;Neuroi waging;Transcutaneous electric nerve stimulation;Acupuncture;Analgesia

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引用本文：

金真, 张蔚婷, 罗非, 张奎伶, 张磊, 曾亚伟, 韩济生. 人脑对不同频率穴位电刺激反应的功能性磁共振成像[J]. 生理学报 2001; 53 (4): .

Jin Zhen, Zhang Weiting, Luo Fei, Zhang Kuiling, Zhang Lei, Zeng Yawei, Han Jisheng. Frequency-specific responses of human brain to peripheral transcutaneous electric nerve stimulation: a functional magnetic resonance imaging study. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).