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皮质酮对大鼠延髓头端腹外侧区神经元活动的影响

王伟忠, 戎伟芳, 王超美, 王建文, 王继江, 袁文俊

第二军医大学生理学教研室.上海 200433

摘要

实验用多管微电极细胞外记录氨基甲酸乙酯麻醉的SD大鼠延髓头端腹外侧区(RVLM)神经元的活动。用电刺激主动脉神经和静脉注射苯肾上腺素激活压力感受器反射等方法鉴定心血管神经元,在RVLM内共记录到145个自发放电的神经元,其中33个为心血管神经元,31个为伤害调制性神经元,81个为未知功能神经元。33个心血管神经元微电泳硫酸皮质酮(CORT)后,25个(76%)神经元放电迅速加快,8个(24%)自发放电没有变化。

关键词： 皮质酮; 头端延髓腹外侧区; 心血管神经元; 伤害调制性神经元; 细胞外记录; 微电泳

Effects of corticosterone on the activity of the neurons in the rostral ventrolateral medulla of rats

Wang Weizhong, Rong Weifang, Wang Chaomei, Wang Jianwen, Wang Jijiang, Yuan Wenjun

Department of Physiology,The Second Military Medical University.Shanghai 200433

Abstract

Results demonstrate that CORT may modulate the activities of the neurons in RVLM through fast non-genomical effect, suggesting that the mechanism of the fast actions of CORT may play an important role in integration of the cardiovascular, nociceptive modulating activity under some conditions such as stress.

Key words: Corticosterone;Rostral ventrolateral medulla;Cardiovascular neuron;Nociceptive modulating neuron;Extracellular cording;Microiontophoresis

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引用本文：

王伟忠, 戎伟芳, 王超美, 王建文, 王继江, 袁文俊. 皮质酮对大鼠延髓头端腹外侧区神经元活动的影响[J]. 生理学报 2001; 53 (4): .

Wang Weizhong, Rong Weifang, Wang Chaomei, Wang Jianwen, Wang Jijiang, Yuan Wenjun. Effects of corticosterone on the activity of the neurons in the rostral ventrolateral medulla of rats. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).