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5-羟色胺抑制谷氨酸对海马神经元的毒性作用

马强, 刘卫, 吴丽颖, 晁福寰

军事医学科学院卫生学环境医学研究所.天津 300050；军事医学科学院药物毒物研究所.北京 100850；军事医学科学院基础医学研究所.北京 100850

摘要

5-HT可明显提高过量Glu作用下海马神经细胞的存活率,减缓Glu对海马脑片CA1区PS的降低作用;在细胞膜上,5-HT可明显减弱Glu诱导的Ca~(2+)内向电流。

关键词： 5-羟色胺(5-HT); 谷氨酸(Glu); 海马神经细胞; 应激

Suppression of glutamate neurotoxicity by 5-HT in hippocampal neurons

Ma Qiang, Liu Wei, Wu Liying, Chao Fuhuan

Institute of Health and Environmental Medicine.Tianjin 300050；China；Institute of Basic Medicine,Academy of Military Medical Sciences.Beijing 100850

Abstract

The effects of excess glutamate on the survival rate of cultured hippocampal neurons, the population spike (PS) of CA1 area of hippocampal slices and the Ca~(2+) current of hippocampal neurons were observed in rats. Decreased survival rate of hippocampal neurons in the presence of excess glutamate was partially reversed by 5-HT, which was in association with a less decrease of PS magnitudes. The Ca~(2+) inward current induced by glutamate was significantly diminished in the presence of 5-HT.

Key words: Serotonin(5-HT);Glutamate(an);Hippocampal neuron;Stress

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引用本文：

马强, 刘卫, 吴丽颖, 晁福寰. 5-羟色胺抑制谷氨酸对海马神经元的毒性作用[J]. 生理学报 2001; 53 (4): .

Ma Qiang, Liu Wei, Wu Liying, Chao Fuhuan. Suppression of glutamate neurotoxicity by 5-HT in hippocampal neurons. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).