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氨基甙类抗生素对家兔离体颈动脉窦压力感受器放电的抑制作用

刘东霞, 钮伟真, 沈靖

首都医科大学心血管研究室.北京 100054

摘要

(1)氨基甙类抗生素特异性地抑制CS-BRA,是一种新的研究压力感受器活动的工具药;(2)钙离子不是形成压力感受器发生器电位的主要离子,而且L-型钙通道在CS-BRA中没有显著作用;(3)氨基甙类抗生素对CS-BRA的抑制作用可能不是通过阻断L-型钙通道实现的。

关键词： 压力感受器; 氨基甙类抗生素; 钙; L-型钙通道阻断剂

Inhibitory effect of aminoglycoside antibiotics on rabbit carotid baroreceptor activity in vitro

Liu Dongxia, Niu Weizhen, Shen Jing

Department of Cardiovascular Physiology,Capital University of Medical Sciences.Beijing 100054

Abstract

These resutls suggest: (1)aminoglycoside antibiotics can inhibit CS-BRA specifically thus providing a new tool for the study of baroreceptors; (2) calcium ions are not necessary for producing generator potentials of baroreceptors, and the L-type calcium channel does not seem to be involved in CS-BRA per se; and (3) the inhibitory effects of aminoglycoside antibiotics on CS-BRA may not be related to the blocking of L-type calcium channels.

Key words: Baroreceptor;Aminoglycoside antibiotics;Calcium;Antagonists of L-type calcium channel

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引用本文：

刘东霞, 钮伟真, 沈靖. 氨基甙类抗生素对家兔离体颈动脉窦压力感受器放电的抑制作用[J]. 生理学报 2001; 53 (2): .

Liu Dongxia, Niu Weizhen, Shen Jing. Inhibitory effect of aminoglycoside antibiotics on rabbit carotid baroreceptor activity in vitro. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).