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Balb/c小鼠左右两侧大脑皮层IL-1#beta#、IL-6含量的不对称性

付清玲, 李康生

汕头大学医学院微生物学与免疫学教研室.广东,汕头 515031

摘要

正常小鼠大脑皮层IL-1#beta#、IL-6含量均为右侧显著高于左侧;LPS刺激后,左侧大脑皮层IL-6含量明显升高,右侧大脑皮层IL-6含量显著高于左侧大脑皮层,而左右侧大脑皮层IL-1#beta#含量无明显差异。该实验结果表明,Balb/c小鼠在正常生理状态下两侧大脑皮层IL-1#beta#、IL-6含量存在不对称性,左右侧大脑皮层免疫调控异质性可能与细胞因子的不对称性有关。

关键词： 不对称性; 大脑皮层; 免疫调控; 白细胞介素1β; 白细胞介素6

Selective distribution of IL-1#beta# and IL-6 contents in the right and left cortices of Balb/c mice

Fu Qingling, Li Kangsheng

Department of Microbiology and Immunology,Medical College,Shantou University.Shantou 515031,Guangdong

Abstract

No statistically significant difference of IL-1#beta# contents was found between the two cerebral cortices, while the IL-6 content of the right cortex was higher than that of the left (P<0.01), suggesting that some cytokines are probably involved in the differences between the right and left cerebral immunomodulatory functions in mice.

Key words: Lateralization;;;;

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引用本文：

付清玲, 李康生. Balb/c小鼠左右两侧大脑皮层IL-1#beta#、IL-6含量的不对称性[J]. 生理学报 2001; 53 (2): .

Fu Qingling, Li Kangsheng. Selective distribution of IL-1#beta# and IL-6 contents in the right and left cortices of Balb/c mice. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).