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低氧预处理提高离体培养的下丘脑细胞缺氧耐受性及其与线粒体膜电位稳定性的关系

吴丽颖, 丁爱石, 马强, 王福庄, 范明

军事医学科学院基础医学研究所神经生物学研究室.北京 100850

摘要

低氧预处理能提高下丘脑细胞的缺氧耐受性,其机制与线粒体膜电位稳定性增强有关;低氧预处理诱发bcl-2高表达可能是线粒体膜电位稳定性增强的机制之一。

关键词： 低氧预处理; 缺氧耐受性; 下丘脑细胞; 线粒体膜电位; bcl-2

Correlation between enhanced anoxic tolerance induced by hypoxic preconditioning and the stability of mitochondrial membrane potential in cultured hypothalamic cells

Wu Liying, Ding Aishi, Ma Qiang, Wang Fuzhuang, Fan Ming

Institute of Basic Medical Sciences,Academy of Military Medical Sciences.Beijing 100850

Abstract

The results suggest that hypoxic preconditioning can enhance the tolerance of hypothalamic cells to anoxia, and the underlying mechanism may be related to increased stability of MMP. Overexpression of bcl-2 induced by hypoxic preconditioning may play a role in sustaining the stability of MMP.

Key words: Hypoxic preconditioning;Anoxic tolerance;Hypothalamic cells;MMP;bcl- 2

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引用本文：

吴丽颖, 丁爱石, 马强, 王福庄, 范明. 低氧预处理提高离体培养的下丘脑细胞缺氧耐受性及其与线粒体膜电位稳定性的关系[J]. 生理学报 2001; 53 (2): .

Wu Liying, Ding Aishi, Ma Qiang, Wang Fuzhuang, Fan Ming. Correlation between enhanced anoxic tolerance induced by hypoxic preconditioning and the stability of mitochondrial membrane potential in cultured hypothalamic cells. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).