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猕猴精浆纤溶酶原激活因子的来源及在精子获能中的作用

郑萍, 邹如金, 刘以训

中科院昆明动物研究所生殖生物学实验室.云南,昆明 650223；中科院动物研究所生殖生物学国家重点实验室.北京 100080

摘要

猕猴附睾、前列腺和精囊均表达tPA、uPA和PAI-1 mRNAs。加入uPA能维持精子的活力,使精子产生超激活运动,诱导顶体反应的发生,并使精子获得激活卵子的能力。这说明猕猴精浆PA除来源于睾丸外,可能主要来源于附睾及附性腺;在体外,uPA,而不是tPA,可能诱导精子获能。

关键词： 猕猴; 纤溶酶原激活因子; 精子获能

Source of plasminogen activator in rhesus monkey semen and its possible role in sperm capacitation

Zheng Ping, Zou Rujin, Liu Yixun

Kunming Institute of Zoology,Chinese Academy of Sciences.Kunming 650223,Yunnan；China

Abstract

Results showed that (1) mRNAs for PA and PAI-1 were expressed in epididymis, seminal vesicle and prostate gland, and (2) uPA, but not tPA, improved sperm mobility, induced AR and enhanced sperm capacity to fertilize mature eggs. Thus, it is concluded that PA activity in semen comes not only from testis and epididymis, but also from seminal vesicle and prostate gland; and that uPA, but not tPA, may play a role in sperm capacitation.

Key words: Rhesus monkey;Plasminogen activator;sperm capacitation

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引用本文：

郑萍, 邹如金, 刘以训. 猕猴精浆纤溶酶原激活因子的来源及在精子获能中的作用[J]. 生理学报 2001; 53 (1): .

Zheng Ping, Zou Rujin, Liu Yixun. Source of plasminogen activator in rhesus monkey semen and its possible role in sperm capacitation. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).