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MAPK信号途径在一氧化氮抑制大鼠心肌肥大中的作用

鲁伟, 刘培庆, 王庭槐, 龚素珍, 符史干, 潘敬运

中山医科大学生理学教研室.广东,广州 510089

摘要

(1)L-精氨酸可明显抑制肾动脉狭窄术后的血压升高、左心室重与体重比增加,增加心肌组织eNOS、MKP-1蛋白表达及亚硝酸盐/硝酸盐含量,降低心肌组织MAPK活性,其中以150mg/kg组作用最为明显;(2)NOS抑制剂L-NAME可明显抑制L-精氨酸的以上作用。肾性高血压大鼠心肌组织eNOS蛋白表达下降。NO生成减少及MKP-1蛋白表达下降以及MAPK活性增强可能与高血压及心肌肥厚形成有关,L-精氨酸通过促进心肌组织eNOS蛋白表达、增加NO产生和MKP-1表达、减弱MAPK活性而发挥抗高血压及心肌肥厚的作用。

关键词： 心肌肥厚; L-精氨酸; 内皮型一氧化氮合酶; 一氧化氮; 丝裂原活化蛋白激酶; 丝裂原活化蛋白激酶磷酸酶-1

Role of mitogen-activated protein kinase in the inhibition of myocardial hypertrophy by nitric oxide in renovascular hypertensive rats

Lu Wei, Liu Peiqing, Wang Tinghuai, Gong Suzhen, Fu Shigan, Pan Jingyun

Department of Physiology,Sun Yat-Sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The aim of this study was to examine the effects of L-arginine, a nitric oxide (NO) precursor, on protein expression of endothelial nitric oxide (eNOS), nitrite/nitrate content, protein expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) and the activity of mitogen-activated protein kinase (MAPK) in cardiac tissues in renovascular hypertensive rats (RHR).

Key words: Myocardial hypertrophy; endothelial nitric oxide (eNOS);;;;

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引用本文：

鲁伟, 刘培庆, 王庭槐, 龚素珍, 符史干, 潘敬运. MAPK信号途径在一氧化氮抑制大鼠心肌肥大中的作用[J]. 生理学报 2001; 53 (1): .

Lu Wei, Liu Peiqing, Wang Tinghuai, Gong Suzhen, Fu Shigan, Pan Jingyun. Role of mitogen-activated protein kinase in the inhibition of myocardial hypertrophy by nitric oxide in renovascular hypertensive rats. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).