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麻醉剂氟烷对心脏毒蕈碱型钾通道的影响

臧伟进, 于晓江, 臧益民

西安医科大学心血管生理药理研究室.陕西，西安 710061；第四军医大学生理教研室.陕西,西安 710032

摘要

神经递质乙酰胆碱（ACh）调节心脏功能最重要的离子通道就是毒蕈碱型钾通道，该通道由Ach经鸟苷酸调节蛋白（G蛋白）的#beta# #gamma#亚单位而激活。本实验采用全细胞膜片箝方法

关键词： 麻醉剂; 心脏; 钾离子通道; 乙酰胆碱

Effect of halothane on the muscarinic potassium current of the heart

Zang Weijin, Yu Xiaojiang, Zang Yimin

Division of Cardiovascular Physiology and Pharmacology, Xi^an Medical Univesity. Xian 710061,Shaanxi；China

Abstract

Acetycholine (ACh) released from parasympathetic nerves binds to muscarinic (M2)ACh receptro (mAChR) in the heart,which leads to activation of muscarinic K~(+) channel via the #Beta# #gamma# subunit of a Gprotein

Key words: General anaesthetics;Heart;Potassium channels;Acetylcholine

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引用本文：

臧伟进, 于晓江, 臧益民. 麻醉剂氟烷对心脏毒蕈碱型钾通道的影响[J]. 生理学报 2000; 52 (2): .

Zang Weijin, Yu Xiaojiang, Zang Yimin. Effect of halothane on the muscarinic potassium current of the heart. Acta Physiol Sin 2000; 52 (2): (in Chinese with English abstract).