过刊浏览

八肽胆囊收缩素减轻肿瘤坏死因子诱导的离体兔肺动脉反应性变化及内皮细胞损伤

孟爱宏, 凌亦凌, 王殿华, 谷振勇, 李淑瑾, 朱铁年

河北医科大学病理生理教研室.河北,石家庄 050017

摘要

应用离体血管环张力测定技术及扫描电镜的方法,观察了八肽胆囊收缩素(CCK-8)对肿瘤坏死因子#alpha#(TNF-#alpha#)引起的肺动脉反应性及肺动脉内皮细胞超微结构变化的影响。结果提示,CCK-8可逆转TNF-#alpha#对内皮依赖性舒张反应的抑制作用,减轻内皮细胞结构损伤,这可能是CCK-8抗内毒素休克时肺动脉高压并具有细胞保护作用的机制之一。

Cholecystokinin-octapeptide alleviates tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity and injuries of endothelium in vitro

Meng Aihong, Ling Yiling, Wang Dianhua, Wu Zhenyong, Li Shujin, Zhu Tienian

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

To explore the mechanism underlying cholecystokinin-octapeptide (CCK-8) induced attenuation of pulmonary arterial hypertension (PAH) in endotoxic shock, the effects of CCK-8 on the changes in rabbit pulmonary arterial reactivity induced by tumor necrosis factor-alpha (TNF-#alpha#) were observed with the isolated arterial ring technique, and the ultrastructure of pulmonary arterial endothelium was observed under a scanning electron microscope.

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

孟爱宏, 凌亦凌, 王殿华, 谷振勇, 李淑瑾, 朱铁年. 八肽胆囊收缩素减轻肿瘤坏死因子诱导的离体兔肺动脉反应性变化及内皮细胞损伤[J]. 生理学报 2000; 52 (6): .

Meng Aihong, Ling Yiling, Wang Dianhua, Wu Zhenyong, Li Shujin, Zhu Tienian. Cholecystokinin-octapeptide alleviates tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity and injuries of endothelium in vitro. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).