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一氧化氮抑制血管紧张素Ⅱ和内皮素-1诱导的心肌细胞原癌基因c-fos表达

詹昌德, 潘敬运

中山医科大学卫生部辅助循环重点实验室.广东,广州 510089；中山医科大学生理学教研室.广东,广州 510089

摘要

NO可抑制AⅡ或ET-1诱导的心肌细胞肥大和原癌基因c-fos表达,其作用机制可能与蛋白激酶C这一环节有关。

Nitric oxide inhibits the expression of proto-oncogene c-fos induced by angiotensin II and endothelin-1 in cardiomyocytes

Zhan Changde, Pan Jingyun

Key Laboratory of the Ministry of Health on Assisted Circulation,Sun Yat-sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

Results suggest that NO can inhibit the hypertrophic response and the proto-oncogene c-fos expression of cardiomyocytes induced by AII or ET-1 and the cross-link may be located at the site of protein kinase C.

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引用本文：

詹昌德, 潘敬运. 一氧化氮抑制血管紧张素Ⅱ和内皮素-1诱导的心肌细胞原癌基因c-fos表达[J]. 生理学报 2000; 52 (6): .

Zhan Changde, Pan Jingyun. Nitric oxide inhibits the expression of proto-oncogene c-fos induced by angiotensin II and endothelin-1 in cardiomyocytes. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).