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一氧化氮供体增强大鼠记忆及其与脑内ADP-核糖基转移酶的关系

李从德, 张世仪, 袁勃

湖北三峡大学医学院生理教研室.湖北,宜昌 443003；医科院基础医学研究所.北京 100005

摘要

用NO供体硝普钠(sodium nitroprusside,SNP)或同时给予ADP-核糖基转移酶(ADP-ribosyltransferase,ADPRT)抑制剂尼克酰胺(nicotinamide,NIC)侧脑室内注射,观察其对大鼠学习记忆行为的影响。并用高效液相色谱法测定脑内ADPRT活性。结果表明,SNP(0.36#mu#g icv)使大鼠在被动回避反应的短时与长时记忆和在主动回避反应的学习记忆能力增强。

Relationship between memory enhancement induced by nitric oxide donor and brain ADP-ribosyltransferase in rats

Li Congde, Zhang Shiyi, Yuan Bo

Medical School,Hubei Three Canyon University.Yichang 443003,Hubei；China

Abstract

In order to explore the signal transduction pathway of nitric oxide (NO) related to learning and memory, the effects of intracerebral ventricular injection (icv) of NO donor sodium nitroprusside (SNP) alone or along with ADP-ribosyltransferase (ADPRT) inhibitor nicotinamide (NIC) on learning and memory behavior were investigated in rats. Brain ADPRT activity was analyzed using high performance liquid chromatography. The results showed that SNP (0.36#mu#g, icv) facilitated short-term and long-term memory in passive avoidance response and elevated learning and memory ability in active avoidance response. NIC (1.5mg, icv) blocked the effect of SNP.

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引用本文：

李从德, 张世仪, 袁勃. 一氧化氮供体增强大鼠记忆及其与脑内ADP-核糖基转移酶的关系[J]. 生理学报 2000; 52 (6): .

Li Congde, Zhang Shiyi, Yuan Bo. Relationship between memory enhancement induced by nitric oxide donor and brain ADP-ribosyltransferase in rats. Acta Physiol Sin 2000; 52 (6): (in Chinese with English abstract).