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茶碱改善东莨菪碱诱发的大鼠记忆障碍

金宗濂, 文镜, 王卫平, 贺闻涛

北京联合大学应用文理学院.北京 100083

摘要

用高效液相色谱测定了不同年龄SD大鼠与记忆有关脑区的腺苷和乙酰胆碱水平。结果表明,18-20月龄鼠的脑内腺苷含量明显高于3-6月龄鼠,而乙酰胆碱(ACh)含量却显著低于3-6月龄鼠。经腹腔给大鼠注射东莨菪碱建立近期记忆障碍模型,同时经脑室给予茶碱后,其跳台成绩明显优于对照组,且脑内ACh含量亦显著升高。

The role of theophylline in the improvement of scop-induced learning and memory impairment

Jin Zonglian, Wen Jing, Wang Weiping, He Wentao

College of Applied Sciences and Humanities of Beijing Union University.Beijing 100083

Abstract

Adenosine and ACh contents in hippocampus, striatum region around the nucleus of basal meynert (NBM) and the frontal and temporal parts of rat cortex were measured by a high performance liquid chromotography-electronic detector (HPLC-ECD). Adenosine content in 180020 month-old rats was significantly higher than that of 3-6 month-old rats, while ACh content in 18-20 month-old rats was lower than that of 3-6 month-old ones. Learning and memory impairment models were established by induction of SD rats with scopolamine (0.5 mg/kg, ip), which were injected with an adenosine recepter antagonist theophylline (1.0 mg/5 #mu#l, icv), and the step-down test was performed.

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引用本文：

金宗濂, 文镜, 王卫平, 贺闻涛. 茶碱改善东莨菪碱诱发的大鼠记忆障碍[J]. 生理学报 2000; 52 (5): 390-394.

Jin Zonglian, Wen Jing, Wang Weiping, He Wentao. The role of theophylline in the improvement of scop-induced learning and memory impairment. Acta Physiol Sin 2000; 52 (5): 390-394 (in Chinese with English abstract).