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中枢外源性胃动素对大鼠脑干胃相关神经元电活动及胃运动的影响

唐明, 张洪燕, 蒋正尧, 徐珞, Peeters T L

青岛大学医学院生理教研室.山东,青岛 266021；比利时鲁汶大学胃肠激素研究室

摘要

用核团或侧脑室微量注射、微电极细胞外单位放电记录及清醒动物胃运动记录等方法,观察了大鼠下丘脑腹内侧区(ventral medial hypothalamus,VMH)或侧脑室内(icv)微量注入胃动素(motilin)对延髓迷走复合体(dorsal vagal complex,DVC)神经元电活动和胃运动的影响。结果表明:(1)VMH注入胃动素会改变DVC胃相关神经元的电活动;(2)VMH及侧脑室内注入胃动素可使清醒大鼠胃运动增强;(3)膈下迷走神经切断会取消VMH增强胃运动的作用。

Effect of central administration of motilin on the activity of gastric-related neurons in brain stem and gastric motility of rats

Tang Ming, Zhang Hongyan, Jiang Zhengyao, Xu Luo, Peeters T L

Department of Physiology,College of Medicine,Qingdao University.Qingdao 266021,Shandong

Abstract

To investigate the effect of microinjection of motilin into ventral medail hypothalamus (VMH) or intracerebroventricle (icv) on gastric motility, extracellular unit responses of dorsal vagal complex (DVC) in anesthetized rats and gastric motility of conscious rats were recorded. The results are as follows. (1) The firing rate of gastric distention related neurons in DVC was modified. (2) VMH and icv administration of motilin induced obvious enhancement in gastric motility. (3) The effect of motilikn on gastric motility was abolished by vagotomy.

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引用本文：

唐明, 张洪燕, 蒋正尧, 徐珞, Peeters T L. 中枢外源性胃动素对大鼠脑干胃相关神经元电活动及胃运动的影响[J]. 生理学报 2000; 52 (5): 416-420.

Tang Ming, Zhang Hongyan, Jiang Zhengyao, Xu Luo, Peeters T L. Effect of central administration of motilin on the activity of gastric-related neurons in brain stem and gastric motility of rats. Acta Physiol Sin 2000; 52 (5): 416-420 (in Chinese with English abstract).