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亚硝基铁氰化钠对脊髓背角神经元诱发与自发反应的影响

王润萍, 林青, 李菁锦, 吕国蔚

首都医科大学神经生物系.北京 100054；美国德州大学医学院解剖与神经科学系.Galveston,TX77555-1069

摘要

用微透析方法在麻醉麻痹大鼠的脊髓局部应用一氧化氮(NO)供体亚硝基铁氰化钠(sodium nitroprusside,SNP),以碳丝微电极在腰膨大处行细胞外记录,观察NO对机械刺激大鼠后足部皮肤引起的诱发反应和自发反应的影响。结果提示:不同浓度的NO对脊髓非伤害性和伤害性信息传递具有不同的作用;NO参与脊髓神经元抗伤害作用并促进其自发活动。

Effect of sodium nitroprusside on the spontaneous and induced responses of rat spinal cord dorsal horn neurons

Wang Runping, Lin Qing, Li Jingjin, Lu Guowei

Department of Neurobiology,Capital University of Medical Science.Beijing 100054

Abstract

The present study was performed on anesthetized and paralyzed Wistar rats. Extracellular recordings were made from the lumbar enlargement of the spinal cord using carbon Filament electrodes. NO donor sodium nitroprusside (SNP) was locally microdialyzed to the spinal cord, and effects of NO on spontaneous response and the responses induced by mechanical stimulation of the hind-foot were observed.

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引用本文：

王润萍, 林青, 李菁锦, 吕国蔚. 亚硝基铁氰化钠对脊髓背角神经元诱发与自发反应的影响[J]. 生理学报 2000; 52 (5): 407-410.

Wang Runping, Lin Qing, Li Jingjin, Lu Guowei. Effect of sodium nitroprusside on the spontaneous and induced responses of rat spinal cord dorsal horn neurons. Acta Physiol Sin 2000; 52 (5): 407-410 (in Chinese with English abstract).