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前包钦格复合体区微量注射氨基酸类药物的呼吸效应

李川, 余微, 郑煜

华西医科大学生理学教研室.四川,成都 610041

摘要

在pre-Bot复合体内注射KA后,所有动物首先出现呼吸兴奋效应,表现为吸气时程(T_(I))延长,呼气时程(T_(E))缩短,呼吸频率(RF)增快;随后出现呼吸抑制效应,表现为呼吸停止于呼气状态。Pre-Bot复合体内注射Glu,引起动物T_(E)缩短,注射Gly或GABA均引起动物T_(I)缩短。

Effects of microinjection of amino acids into pre-Botzinger complex on respiration in adult rats

Li Chuan, Yu Wei, Zheng Yu

Department of Physiology,West China University of Medical Sciences.Chengdu 610041,Sichuan

Abstract

Experiments were performed on sodium pentobarbital anesthetized and bilaterally vagotomized adult SD rats. Microinjection of an excitatory neurotoxin, kainic acid, into pre-Botzinger complex initially lengthened the duration of inspiration, shortened the duration of expiration and increased the respiratory frequency, and subsequently abolished rhythmic respiration. Injection of an excitatory amino acid, L-glutamate, shortened the duration of expiration. Injection of the inhibitory amino acids (either glycine or #gamma#-aminobutyric acid) shortened the duration of inspiration.

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引用本文:

李川, 余微, 郑煜. 前包钦格复合体区微量注射氨基酸类药物的呼吸效应[J]. 生理学报 2000; 52 (4): .

Li Chuan, Yu Wei, Zheng Yu. Effects of microinjection of amino acids into pre-Botzinger complex on respiration in adult rats. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).