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最后区注射腺苷对大鼠血压、心率和肾交感神经放电的影响

陈爽, 李德培, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

53只麻醉Sprague-Dawley大鼠在最后区内微量注射腺苷(1ng/60nl)后平均动脉压(MAP)、心率(HR)和肾交感神经放电(RSNA)分别由13.76±0.46kPa、356.28±4.25bpm和100±0%下降至11.23±0.49kPa(P<0.001)、336.91±5.23bpm(P<0.01)和70.95±5.19%(P<0.001);iv非选择性腺苷受体拮抗剂8-苯茶碱,150#mu#g/kg,0.2ml)和选择性腺苷A_(1)受体拮抗剂(500#mu#g/kg,0.2ml)后,腺苷的上述抑制效应可被完全阻断;iv ATP敏感性钾通道阻断剂格列苯脲(5mg/kg,0.2ml)后,腺苷的上述效应也被消除。

Effects of microinjection of adenosine into area postrema on heart rate, blood pressure and renal sympathetic nerve activity in rats

Chen Shuang, Li Depei, He Ruirong

Department of Physiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

Following microinjection of Ado (1 ng/60 nl) into AP, MAP, HR and RSNA were decreased from 13.76±0.46 kPa, 356.28±4.25 bpm and 100±0% to 11.23±0.49 kPa (P<0.001), 336.91±5.23 bpm (P<0.01) and 70.95±5.19% (P<0.001), respectively; 8-phenyltheophylline (150 #mu#g/kg, 0.2 ml, iv), a nonselective adenosine receptor antagonist, and 8-cyclopentyl-1, 3-dipropylxanthine (500 #mu#g/kg, 0.2 ml, iv), a selective A_(1) adenosine receptor antagonist, blocked the inhibitory effect of Ado completely; and glibenclamide (5 mg/kg, 0.2 ml, iv), a blocker of ATP-sensitive potassium channel, also abolished the effect of Ado.

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引用本文：

陈爽, 李德培, 何瑞荣. 最后区注射腺苷对大鼠血压、心率和肾交感神经放电的影响[J]. 生理学报 2000; 52 (4): .

Chen Shuang, Li Depei, He Ruirong. Effects of microinjection of adenosine into area postrema on heart rate, blood pressure and renal sympathetic nerve activity in rats. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).