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侧脑室注射血管紧张素Ⅱ对大鼠血压和缰核内神经元电活动的影响

崔金娟, 王绍, 张艳

河南医科大学生理教研室.河南,郑州 450052；白求恩医科大学生理教研室.吉林,长春 130021；河南医科大学药理教研室.河南,郑州 450052

摘要

icv AⅡ或ST-AⅡ,正常鼠和SIH大鼠血压均升高或降低,SIH鼠较正常鼠血压变化更显著(P<0.05);icv AⅡ或微电泳AⅡ明显增强Hb内心血管神经元的放电活动,对SIH大鼠作用更明显;而微电泳ST-AⅡ则明显抑制Hb内心血管神经元的放电活动,对SIH大鼠的抑制作用更强。

Effects of intracerebroventricular injection of angiotensin II on blood pressure and discharges of habenula nucleus cardiovascular neurons

Cui Jinjuan, Wang Shao, Zhang Yan

Department of Physiology,Henan Medical University.Zhengzhou 450052,Henan；China

Abstract

Increase and decrease of BP could be induced respectively by icv of AII (20#mu#g) and ST-AII (20#mu#g), to a greater entent in SIH than in the normotensive group. Icv AII also increased the ENG of MHb cardiovascular neurons in both the groups, but the increase was significantly greater in SIH group than in the nomotensive one. Iontophoretic application of AII increased the ENG of Hb cardiovascular neurons in both the groups and the increase was also significantly greater in SIH than in the normotensive group. On the other hand, iontophoretic application of ST-AII inhibited the ENG of Hb cardiovascular neurons in the two groups and the inhibition was markedly greater in SIH than in the normotensive rats.

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引用本文：

崔金娟, 王绍, 张艳. 侧脑室注射血管紧张素Ⅱ对大鼠血压和缰核内神经元电活动的影响[J]. 生理学报 2000; 52 (4): .

Cui Jinjuan, Wang Shao, Zhang Yan. Effects of intracerebroventricular injection of angiotensin II on blood pressure and discharges of habenula nucleus cardiovascular neurons. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).