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腺苷抑制海马神经元自发放电和谷氨酸所致癫痫样放电

王红, 王志安, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

应用细胞外记录单位放电技术,在大鼠海马脑片上观察腺苷(Ado)对CA1区神经元自发和谷氨酸所致癫痫样放电的影响。实验结果提示:Ado与海马神经元上的A1受体结合后,引起细胞膜上的ATP敏感性钾通道的开放,从而对海马神经元自发放电及Glu所致的癫痫样放电呈现抑制作用。

Adenosine inhibits spontaneous and glutamate-induced discharges of hippocampal CA1 neurons

Wang Hong, Wang Zhian, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

Effects of adenosine (Ado) on spontaneous and glutamate-induced discharges of neurons in CA1 area of hippocampal slices were examined using extracellular recording technique. The results are suggested that Ado can bind with adenosine A1-receptors on CA1 neurons, resulting in an activation of K_(ATP) channels and inhibition of neuronal activity. The inhibitory effect of Ado on glutamate-induced epileptiform activities in rat hippocampal neurons is also mediated by adenosine A1-receptor with involvement of ATP-sensitive potassium channels.

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引用本文：

王红, 王志安, 何瑞荣. 腺苷抑制海马神经元自发放电和谷氨酸所致癫痫样放电[J]. 生理学报 2000; 52 (4): .

Wang Hong, Wang Zhian, He Ruirong. Adenosine inhibits spontaneous and glutamate-induced discharges of hippocampal CA1 neurons. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).