过刊浏览

MAPK信号转导通路对炎症反应的调控

姜勇, 龚小卫

第一军医大学病理生理教研室暨全军休克微循环重点实验室.广东,广州 510515

摘要

丝裂原活化蛋白激酶(MAPK)是生物体内重要的信号转导系统之一,参与介导生长、发育、分裂、分化、死亡以及细胞间的功能同步等多种细胞过程。在哺乳动物细胞中已发现和克隆了ERK、JNK/SAPK、p38/RK、ERK5/BMK1四个MAPK亚族。这些MAPK能被多种炎性刺激所激活,并对炎症的发生、发展起重要调控作用。研究感染和炎症反应过程中这些MAPK被激活的机制及其生物学效应,探讨MAPK特异性抑制剂的药理学作用及分子基础,对于感染的防治及炎症反应的控制有着广泛的应用前景。

Regulation of inflammatory responses by MAPK signal transduction pathways

Jiang Yong, Gong Xiaowei

Department of Pathophysiology and Key Laboratory for Shock and Microcirculation of PLA,First Military Medical University.Guangzhou 510515,Guangdong

Abstract

Mitogen-activated protein kinase (MAPK), which is one of the important signal transduction systems in organisms, is involved in many cellular processes, such as cell growth, development, division, differentiation, death and coordination of cellular functions, and etc. Four subfamilies of MAP kinases, i.e. ERK, JNK/SAPK, p38/RK and ERK5/BMK1, have been identified and cloned in mammalian cells. These MAP kinases are activated by many proinflammatory stimuli and play an important role in the pathogenesis and development of inflammation. In this article recent advances in the study of the mechanisms underlying activation of MAPKs in infection and inflammation and the molecular basis of specific inhibitors for MAPKs are reviewed, in special reference with the perspective prevention and treatment of inflammation by these kinases.

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

姜勇, 龚小卫. MAPK信号转导通路对炎症反应的调控[J]. 生理学报 2000; 52 (4): .

Jiang Yong, Gong Xiaowei. Regulation of inflammatory responses by MAPK signal transduction pathways. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).