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运动诱导的低铁状态大鼠骨髓细胞铁摄入的变化

肖德生, 钱忠明

镇江医学院生理学教研室.江苏, 镇江 212001；香港理工大学应用生物及化学科技学系.香港, 九龙

摘要

大鼠随机分为6个月的运动组（EG）和对照组（SG）。SG平均每个幼红细胞Tf受体数为890 150±164 849个，而在EG为2 175 360±462 737个（P<0.05），但受体的解离常数不受运动影响。EG中Tf的内吞平台和胞内铁聚积速度显著高于SG，胞浆和胞内膜性成分中Tf结合铁和Fe（Ⅱ）摄入增加。EG的胞浆内Fe（Ⅱ）摄入的米氏常数值降低；细胞膜性成分中Fe（Ⅱ）摄入的最大速度增加。

关键词： 铁代谢; 运动; 转铁蛋白受体; 骨髓

Changes in the iron uptake of bone marrow cell in exercised rats

Xiao Desheng, Qian Zhongming

Department of physiology, Zhenjiang Medical Collage. Zhenjiang 212001；China

Abstract

At the end of a 6-month period, the bone marrow cells were freshly isolated . The Tf receptor number on the surface of erythroblasts was 890 150±164 849 molecules/cell in SG and 2 175 360±462 737 molecules /cell in EG(P<0.05) . No significant difference in dissociation constant value was found between the two groups . The plateau of Tf internalization and the rates of cellular iron accumulation in EG were significantly higher than controls . Amounts of Tf-bound iron and Fe(II uptake into cytosolic or stromal fractions were significantly higher in EG than those in cytosolic or stromal fractions of SG . With respect to the specific process of Fe(II), the michaelis constant value of iron uptake into the cytosol, rather than the stroma,in EG was significantly lower than that in SG;and the maximum rate of iron uptake into the stroma in EG was significantly higher than that in SG.

Key words: Iron metabolism;Exercise;Transferrin receptor;Bone marrow

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引用本文：

肖德生, 钱忠明. 运动诱导的低铁状态大鼠骨髓细胞铁摄入的变化[J]. 生理学报 2000; 52 (2): .

Xiao Desheng, Qian Zhongming. Changes in the iron uptake of bone marrow cell in exercised rats. Acta Physiol Sin 2000; 52 (2): (in Chinese with English abstract).