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microRNA-15家族功能研究进展

刘丽凤, 王禹^*

中国人民解放军总医院老年心血管病研究所，北京 100853

摘要

微小RNA (microRNAs, miRNAs)是一类具有转录后调节作用的短小的内源性非编码RNA，其中miR-15家族参与凋亡、细胞分化与周期调控、应激等重要细胞功能活动的调节，并与多种人类疾病如肿瘤、心血管疾病、神经退行性疾病等相关，具有潜在的治疗前景及干预价值。本文就miR-15家族的重要功能及治疗应用前景作一综述。

关键词： 微小RNA; miR-15家族; 凋亡; 肿瘤; 心血管疾病

分类号：R34

[Cellular function of microRNA-15 family.] [Article in Chinese]

LIU Li-Feng, WANG Yu^*

Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China

Abstract

microRNAs (miRNAs) are non-coding endogenous short RNAs which are involved in regulating gene expression at the post-transcriptional level. miR-15 family is increasingly found to play great roles in important cell processes, such as apoptosis, cell differentiation and stress response. Growing evidence indicates that miR-15 family members are implicated in tumor, cardiovascular disease and neurodegenerative disease. miRNAs have emerged as a new promising subset of therapeutic targets. The present paper reviewed the important function of miR-15 family and new approaches for miRNA-based therapy.

Key words: microRNAs; miR-15 family; apoptosis; neoplasm; cardiovascular disease

收稿日期：2011-06-28　　录用日期：2011-08-23

通讯作者：王禹　　E-mail: wangyuheart@163.com

引用本文：

刘丽凤, 王禹. microRNA-15家族功能研究进展[J]. 生理学报 2012; 64 (1): 101-106.

LIU Li-Feng, WANG Yu. [Cellular function of microRNA-15 family.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (1): 101-106 (in Chinese with English abstract).