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降钙素基因相关肽在豚鼠冠脉血流量和心脏传导系统作用的比较

钮伟真, 高燕丽, 刘萍, 刘北英, 叶刚

首都医科大学心血管研究室.北京 100054

摘要

观察应用CGRP前后的冠脉流量、自主心率、在相同心房周期下的房室结(AH)及希浦系传导时间(HV)、心脏出现3:2文氏传导及2:1房室传导阻滞所需的最长起搏周期(PCL3:2,PCL2:1)。CGRP(3-30nmol/L)可显著增加冠脉流量;CGRP(30nmol/L)仅使自主心率轻度增加;CGRP(3-30nmol/L)对AH和HV未产生明显影响,也不影响PCL3:2和PCL2:1。

A comparison of calcitonin gene-related peptide effects on coronary flow and cardiac conduction system in the guinea pig

Niu Weizhen, Gao Yanli, Liu Ping, Liu Beiying, Ye Gang

Department of Cardiovascular Physiology,Capital University of Medical Sciences.Beijing 100054

Abstract

The coronary flow (CF) was measured and the right atrium was paced at incremental frequencies periodically. Perfusing heart with CGRP at the concentrations of 3-30 nmol/L inicreased CF strikingly and dose-dependently. CGRP (30 nmol/L) caused a moderate and significant increase in the spontaneous heart rate, but failed to influence the atrioventricular nodal and His bundle-Purkinje fiber conduction time and the longest atrial pacing cycle length inducing 3:2 Wenckebach and 2:1 AV nodal conduction.

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引用本文：

钮伟真, 高燕丽, 刘萍, 刘北英, 叶刚. 降钙素基因相关肽在豚鼠冠脉血流量和心脏传导系统作用的比较[J]. 生理学报 2000; 52 (3): .

Niu Weizhen, Gao Yanli, Liu Ping, Liu Beiying, Ye Gang. A comparison of calcitonin gene-related peptide effects on coronary flow and cardiac conduction system in the guinea pig. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).