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延髓头端腹外侧区血管升压素能机制在应激性高血粘度中的作用

赵幼梅, 沈旭华, 郭学勤

上海医学高等专科学校生理教研室.上海 201400；上海医学高等专科学校药理教研室.上海 201400；上海医科大学生理教研室.上海 200032

摘要

观察延髓头端腹外侧区(rVLM)微量注射血管升压素(AVP)能否影响正常大鼠的血压和血粘度,并分析rVLM内AVP能机制在清醒大鼠经悬吊加束缚引起应激性升压反应和高血粘度中的影响。结果表明:rVLM内AVP能受体激活可参与rVLM内注入AVP引起的血压和血粘度升高或束缚诱发的应激性升压反应和高血粘度。

AVP-ergic mechanism in the rostral ventrolateral medulla: A possible role in stress-induced hyperviscosity

Zhao Youmei, Shen Xuhua, Guo Xueqin

Department of Physiology,Shanghai Medical College.Shanghai 201400；China

Abstract

The study was undertaken to find whether microinjection of vasopressin (AVP) into the rostral ventrolateral medulla (rVLM) affects blood pressure (BP) and blood viscosity in rats and to analyze the effects of AVP-ergic mechanism in the rVLM on stress-induced hyperviscosity of rats. The results suggest that the increase of BP and plasma viscosity induced by microinjection of AVP into rVLM and the stress-induced pressor response and hyperviscosity caused by restraining may be mediated by activation of the AVP V_(1) receptor in the rVLM.

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引用本文：

赵幼梅, 沈旭华, 郭学勤. 延髓头端腹外侧区血管升压素能机制在应激性高血粘度中的作用[J]. 生理学报 2000; 52 (3): .

Zhao Youmei, Shen Xuhua, Guo Xueqin. AVP-ergic mechanism in the rostral ventrolateral medulla: A possible role in stress-induced hyperviscosity. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).