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多巴胺受体激动剂对兔动脉cAMP产生系统的影响

朱琳, 赵荣瑞, 张玮芳

河南医科大学第一附属医院药剂科.河南,郑州 450052；山西医科大学生理学教研室.山西,太原 030001

摘要

实验观察了选择性多巴胺(DA)DA_(1)受体激动剂fenoldopam与DA_(2)受体激动剂propyl-butyl-dopamine(PBDA)对兔肾动脉,肺、肠系膜动脉和股动脉环磷酸腺苷(cAMP)产生系统的影响。结果提示,在肺动脉、肾动脉和肠系膜动脉上存在DA_(1)受体介导的cAMP产生系统,而在股动脉仅有DA_(2)受体介导的cAMP产生系统。在肠系膜动脉既存在DA_(2)受体介导的cAMP产生系统,又存在DA_(1)受体介导的cAMP产生系统。PBDA既有通过刺激DA_(2)受体抑制AC活性的作用,又有刺激DA_(1)受体而激活AC活性、增加cAMP的效应。

Effects of dopamine receptor agonists on the cAMP content in arteries of the rabbit

Zhu Lin, Zhao Rongrui, Zhang Weifang

Department of Pharmacy,The First Affiliated Hospital,Henan Medical University.Zhengzhou 450052,Henan；China

Abstract

Effects of selective dopamine-1 (DA_(1)) receptor agonist fenoldopam and dopamine-2 (DA_(2)) receptor agonist propyl-butyl-dopamine (PBDA) on the cAMP generation system in renal, pulmonary, mesenteric and femoral arteries of rabbits were studied. Findings suggest the presence of DA_(1) receptors mediating the cAMP generation system in renal, pulmonary and mesenteric arteries, but only DA_(2) receptors in femoral artery, and both DA_(1) and DA_(2) receptors in mesenteric artery. PBDA inhibits the AC activity via stimulation of DA_(2) receptors and increases the AC activity via stimulation of DA_(1) receptors.

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引用本文：

朱琳, 赵荣瑞, 张玮芳. 多巴胺受体激动剂对兔动脉cAMP产生系统的影响[J]. 生理学报 2000; 52 (3): .

Zhu Lin, Zhao Rongrui, Zhang Weifang. Effects of dopamine receptor agonists on the cAMP content in arteries of the rabbit. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).