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双眼和单眼视觉剥夺猫外膝体细胞的图形适应

王伟, 寿天德

中国科技大学生命科学学院视觉研究实验室.安徽,合肥 230027

摘要

为测定丘脑外膝体细胞的图形适应是否依赖于早期视觉经验,在细胞外记录了双眼和单眼缝合的猫外膝体中继细胞对长时间运动光栅刺激的反应。在双眼剥夺猫,占68%的记录到的细胞在30s内反应下降到稳定值,其平均反应值下降33%,适应程度较正常猫显著。在单眼剥夺猫,记录到的剥夺眼驱动的和非剥夺眼驱动的细胞中,分别有占53%和44%的细胞显示图形适应,两者差别不大。研究表明,早期视剥夺能增强或保持图形适应,提示图形适应是外膝体细胞常见的固有性质,可能主要由遗传因素所决定。

Pattern adaptation of relay cells in the lateral geniculate nucleus of binocular and monocular vision-deprived cats

Wang Wei, Shou Tiande

Vision Research Laboratory,School of Life Sciences,University of Science and Technology of China.Hefei 230027,Anhui

Abstract

To test whether the pattern adaptation in thalamus is dependent upon postnatal visual experience during early life, the responses of relay cells to prolonged drifting grating stimulation were recorded extracellularly from the dorsal lateral geniculate nucleus (dLGN) of cats reared with binocular and monocular lid suture. In binocular vision-deprived cats, 68% of cells recorded showed significant adaptation to prolonged grating stimuli within 30s, with a mean response decrease of 33%, and then stabilized gradually. This adaptation was stronger than that of relay cells in normal cats. In monocular vision-deprived cats, 53% of the cells driven by the deprived eye showed similar adaptation as did 44% of the cells driven by the non-deprived eye. These results indicate that pattern adaptation could be maintained or even enhanced after visual deprivation in early life. It is suggested that pattern adaptation is a general and intrinsic property of the dLGN cells, which may be mainly determined by genetic factors.

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引用本文：

王伟, 寿天德. 双眼和单眼视觉剥夺猫外膝体细胞的图形适应[J]. 生理学报 2000; 52 (3): .

Wang Wei, Shou Tiande. Pattern adaptation of relay cells in the lateral geniculate nucleus of binocular and monocular vision-deprived cats. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).