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吗啡耐受增加福尔马林致痛大鼠脊髓Fos和NADPH-d阳性神经元的表达

曹君利, 曾因明, 张励才, 段世明

徐州医学院附属医院麻醉科.江苏,徐州 221002；江苏省麻醉学重点实验室.江苏,徐州 221002

摘要

运用Fos免疫组织化学、NADPH-d组织化学及Fos/NADPH-d双标技术,研究了吗啡耐受对福尔马林致痛大鼠脊髓Fos、NADPH-d阳性及Fos/NADPH-d双标神经元表达的影响。结果提示,NO参与了吗啡耐受导致的脊髓背角神经元敏感化。

关键词： 吗啡; 耐受; Fos-LI; 一氧化氮合酶（NOS）

Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats

Cao Junli, Zeng Yinming, Zhang Licai, Duan Shiming

Department of Anesthesiology,Affiliated Hospital of Xuzhou Medical College.Xuzhou 221002,Jiangsu；China

Abstract

Fos immunocytochemistry, NADPH-d histochemistry and Fos/NADPH-d double-labeling method were used to study the changes in formalin-induced Fos, NADPH-d positive and Fos/NADPH-d double-labeled neurons in the spinal cord of morphine-tolerant rats. It is suggested that NO is involved in the increase of formalin-induced Fos-LI in the spinal cord of morphine-tolerant rats and may play an important role in the development of morphine tolerance.

Key words: Morphine;Tolerance;Fos-LI;Nitric oxide synthase

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引用本文：

曹君利, 曾因明, 张励才, 段世明. 吗啡耐受增加福尔马林致痛大鼠脊髓Fos和NADPH-d阳性神经元的表达[J]. 生理学报 2000; 52 (3): .

Cao Junli, Zeng Yinming, Zhang Licai, Duan Shiming. Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).