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褪黑素对大鼠下丘脑薄片视交叉上核神经元放电昼夜节律性的调制

周先举, 蒋星红, 俞光第, 印其章

苏州医学院神经生物学研究室.江苏,苏州 215007

摘要

先用持续光照和松果腺切除预处理大鼠,然后制成下丘脑薄片,记录其视交叉上核(SCN)神经元的自发放电,观察其昼夜变化和褪黑素(MEL)对它的影响。实验结果显示,松果腺作为大鼠昼夜节律组构的一个调整器,通过MEL作用于SCN中的高亲和性ML-1受体,在反应的两个时间窗口(CT8-10和CT22-24)调节SCN的昼夜节律活动。

关键词： 视交叉上核; 松果腺切除; 褪黑素; 下丘脑薄片; 昼夜节律; luzindole; 哌唑嗪

Modulation of circadian rhythm of discharges of suprachiasmatic nucleus neurons in rat hypothalamic slices by melatonin

Zhou Xianju, Jiang Xinghong, Yu Guangdi, Yin Qizhang

Laboratory of Neurobiology,Suzhou Medical College.Suzhou 215007,Jiangsu

Abstract

Spontaneous firing of suprachiasmatic nucleus (SCN) neurons and the effect of melatonin (MEL) were examined in hypothalamic slices made from pinealectomized rats or from the rats exposed to constant light. The results suggest that pineal gland, as a regulator of the organization of circadian rhythm, regulates the circadian rhythm of SCN neurons at two responsive time windows (CT8-10 and CT22-24) through high affinity ML-1 receptors in SCN.

Key words: Suprachiasmatic nucleus;Pinealectomy;Melatonin;Hypothalamic slice;Circadian rhythm;Luzindole prazosin;

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引用本文：

周先举, 蒋星红, 俞光第, 印其章. 褪黑素对大鼠下丘脑薄片视交叉上核神经元放电昼夜节律性的调制[J]. 生理学报 2000; 52 (3): .

Zhou Xianju, Jiang Xinghong, Yu Guangdi, Yin Qizhang. Modulation of circadian rhythm of discharges of suprachiasmatic nucleus neurons in rat hypothalamic slices by melatonin. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).