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NO在胆道加压引起的反射活动中的作用

张敏, 丁春华, 张连巍, 杨思禹

河北医科大学病理生理学教研室.河北,石家庄 050017；河北医科大学门诊部.河北,石家庄 050017

摘要

向胆道加压至4 kPa,可同时引起血压降低和Oddi括约肌(SO)肌电活动减弱或消失,这总称为胆道加压反射,其中前者称为胆道-血压反射,后者称为胆道-SO反射。该实验应用32只家兔观察一氧化氮(NO)对胆道加压反射活动的影响。结果提示,这两种反射活动是相对独立的,是经不同传出途径和效应器实现的;且这两种反射都主要是通过NO介导的。

关键词： 一氧化氮; Oddi括约肌; 胆道-SO反射; 胆道血压反射; 家兔

Role of nitric oxide in the reflex of raising biliary pressure

Zhang Min, Ding Chunhua, Zhang Lianwei, Yang Siyu

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei；China

Abstract

Raising the biliary tract pressure from the baseline to 4 kPa significantly decreases arterial blood pressure and myoelectric activity of sphincter of Oddi (SO) (bile duct-arterial blood pressure reflex), which is sometimes associated with the disappearance of phasic myoelectric activity of SO (bile duct-SO reflex). Thirty-two rabbits were used to investigate the role of nitric oxide (NO) in these reflexes. Findings suggest that both of these two reflexs are caused by the tension stimulation to the receptive area of the biliary tract, and may be mediated by NO.

Key words: Calcium;Current;Antrial circular;Smooth muscle cells;Stretch

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引用本文：

张敏, 丁春华, 张连巍, 杨思禹. NO在胆道加压引起的反射活动中的作用[J]. 生理学报 2000; 52 (1): .

Zhang Min, Ding Chunhua, Zhang Lianwei, Yang Siyu. Role of nitric oxide in the reflex of raising biliary pressure. Acta Physiol Sin 2000; 52 (1): (in Chinese with English abstract).