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辣椒素对大鼠延髓腹外侧头端区神经元电活动的影响

薛保建, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

在35只切断两侧缓冲神经的麻醉大鼠,应用细胞外记录的电生理学方法,观察颈总动脉注射辣椒素(capsaicin)对延髓腹外侧头端区(RVLM)巨细胞旁外侧核(PGL)自发电活动的影响。结果提示,辣椒素可能通过激活RVLM神经元上的辣椒素受体,进而兴奋PGL神经元。

关键词： 辣椒素; RVLM神经元自发放电; 辣椒素受体; 钌红

Effects of intracarotid injection of capsaicin on electrical activity of rostral ventrolateral medullary neurons in rats

Xue Baojian, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The effects of intracarotid injection of capsaicin on spontaneous electrical activity of nucleus paragigantocellularis lateralis (PGL) neurons in rostral ventrolateral medulla (RVLM) were examined in 35 anesthetized rats with sino-aortic denervation by using extracellular recording technique. Results suggest that capsaicin may stimulate the vanilloid receptor of neurons in RVLM, thereby resulting in activation of PGL neurons.

Key words: Capsaicin;Spontaneous discharge of neurons in RVLM;Capsaicin receptor;Ruthenium red

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引用本文：

薛保建, 何瑞荣. 辣椒素对大鼠延髓腹外侧头端区神经元电活动的影响[J]. 生理学报 1999; 51 (6): .

Xue Baojian, He Ruirong. Effects of intracarotid injection of capsaicin on electrical activity of rostral ventrolateral medullary neurons in rats. Acta Physiol Sin 1999; 51 (6): (in Chinese with English abstract).