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蛋白激酶A介导慢性压迫背根节神经元的肾上腺素能兴奋反应

徐晖, 胡三觉, 韩勇, 龙开平

第四军医大学生理学教研室.陕西,西安 710033；第四军医大学神经科学研究所.陕西,西安 710033；第四军医大学唐都医院胸外科.陕西,西安 710033

摘要

在DRG慢性压迫模型上,损伤的DRG神经元存在肾上腺素能敏感性,#alpha#_(1)和#alpha#_(2)肾上腺素受体以及PKA介导兴奋性肾上腺素能敏感化作用。

关键词： 肾上腺素能敏感性; 自发放电; 脊神经节; 传入神经元; 蛋白激酶A

Protein kinase a mediated excitatory adrenergic effect on chronically compressed dorsal root ganglion neurons in rats

Xu Hui, Hu Sanjue, Han Yong, Long Kaiping

Department of Physiology,The Fourth Military Medical University.Xi^an 710033,Shaanxi；China；Department of Thoracic Surgery,Tang Du Hospital,The Fourth Military Medical University.Xi^an 710033,Shaanxi

Abstract

The results demonstrate that injury to DRG neuron body triggered the adrenosensitivity, which was mediated #alpha#_(1), #alpha#_(2) adrenoceptors and PKA.

Key words: Adrenosensitivity;Spontaneous activity;Spinal ganglion;Afferent neurons;Protein kinase A

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引用本文：

徐晖, 胡三觉, 韩勇, 龙开平. 蛋白激酶A介导慢性压迫背根节神经元的肾上腺素能兴奋反应[J]. 生理学报 1999; 51 (6): .

Xu Hui, Hu Sanjue, Han Yong, Long Kaiping. Protein kinase a mediated excitatory adrenergic effect on chronically compressed dorsal root ganglion neurons in rats. Acta Physiol Sin 1999; 51 (6): (in Chinese with English abstract).