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蝎毒诱导红藻氨酸癫痫大鼠海马内GABA释放的免疫组化观察

姜春玲, 张万琴

大连医科大学生理教研室.辽宁,大连 116027

摘要

蝎毒能选择性防止癫痫敏感大鼠腹侧海马GABA能中间神经元的损伤,并使GABA的释放量增加。提示此效应很可能是蝎毒抗癫痫反复发作的重要机制之一。

关键词： 东亚钳蝎粗毒; 抗癫痫反复发作; 腹侧海马; GABA免疫反应样物质(GABAIR)

Effect of scorpion venom on the release of GABA in hippocampus of epileptic rats induced by kainic acid

Jiang Chunling, Zhang Wanqin

Department of Physiology,Dalian Medical University.Dalian 116027,Liaoning

Abstract

The result suggest that SV may selectively prevent loss of GABAergic interneurons in the ventral hippocampus of rats susceptible to epileptic seizures and increase the release of GABA as an antiepileptic mechanism.

Key words: Scorpion venom;Antiepileptic susceptibility;Ventral hippocampus;#gamma#-aminobutyric acid immunoreactivity (GABAIR)

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引用本文：

姜春玲, 张万琴. 蝎毒诱导红藻氨酸癫痫大鼠海马内GABA释放的免疫组化观察[J]. 生理学报 1999; 51 (6): .

Jiang Chunling, Zhang Wanqin. Effect of scorpion venom on the release of GABA in hippocampus of epileptic rats induced by kainic acid. Acta Physiol Sin 1999; 51 (6): (in Chinese with English abstract).