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慢性低氧对豚鼠右室心肌细胞钙、钾电流的影响

别毕华, 张珍祥, 徐永健, 岳远坤, 唐明

同济医科大学附属同济医院呼吸内科.湖北,武汉 430030；同济医科大学生理教研室.湖北,武汉 430030

摘要

采用全细胞膜片箝技术,分别记录并比较正常对照组与慢性低氧组豚鼠单个右室心肌细胞的膜电容、L型钙电流和延迟整流钾电流峰值和电流-电压关系曲线,以探讨慢性低氧对豚鼠右室心肌细胞L型钙电流和延迟整流钾电流的影响。

关键词： 肺动脉高压; 心肌细胞; 钙电流; 膜片箝; 延迟整流钾电流

Effect of chronic hypoxia on the calcium and potassium current of myocytes of the right ventricle in guinea pig

Bei Bihua, Zhang Zhenxiang, Xu Yongjian, Yue Yuankun, Tang Ming

Divisioni of Respiratory Medicine,Tongji Hospital,Tongji Medical University.Wuhan 430030,Hubei；China

Abstract

To explore the effect of chronic hypoxia on calcium and potassium currents of the right ventricle myocytes in the guinea pig, the cell membrane capacities, calcium and delayed rectifier potassium current were recorded using the whole-cell patch clamp technique from single right ventricle myocytes in guinea pigs under chronic hypoxia.

Key words: Pulmonary hypertension;Cardiomyocyte;Patch clamp;Calcium current;Delayed rectifier potassium current

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引用本文：

别毕华, 张珍祥, 徐永健, 岳远坤, 唐明. 慢性低氧对豚鼠右室心肌细胞钙、钾电流的影响[J]. 生理学报 1999; 51 (5): .

Bei Bihua, Zhang Zhenxiang, Xu Yongjian, Yue Yuankun, Tang Ming. Effect of chronic hypoxia on the calcium and potassium current of myocytes of the right ventricle in guinea pig. Acta Physiol Sin 1999; 51 (5): (in Chinese with English abstract).