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血管紧张素Ⅱ对培养心肌细胞c-fos表达和蛋白质合成的作用

谈世进, 潘敬运, 詹澄扬, 朱晓南

上海市第六人民医院心内科.上海 200233；广州中山医科大学生理教研室.广东,广州 510089

摘要

血管紧张素Ⅱ能诱导c-fos mRNA的表达,增加蛋白质含量,并呈量-效关系;还能加速~(3)H-亮氨酸的掺入速度。上述这些作用可被血管紧张素Ⅱ受体拮抗剂saralasin所阻断。血管紧张素Ⅱ诱导c-fos mRNA的表达亦可被钙通道阻滞剂nicardipine所阻断。

关键词： 血管紧张素Ⅱ; saralasin nicardipine; c-fosmRNA; 蛋白质合成

Effect of angiotensin II on c-fos expression and protein synthesis in cultured rat myocardial cells

Tan Shijin, Pan Jingyun, Zhan Chengyang, Zhu Xiaonan

Department of Cardiology,Shanghai Sixth People^s Hospital.Shanghai 200233；China

Abstract

The results showed that angiotensin II induced c-fos mRNA expression, increased protein content in a dose-dependent manner and stimulated ~(3)H-leucine incorporation rate. All these effects were blocked by angiotensin II receptor antagonist saralasin. The angiotensin II-induced expression of c-fos gene was also blocked by Ca~(2+) channel antagonist nicardipine.

Key words: Angiotensin Ⅱ;Saralasin nicardipine;c-fos mRNA;Protein synthesis

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引用本文：

谈世进, 潘敬运, 詹澄扬, 朱晓南. 血管紧张素Ⅱ对培养心肌细胞c-fos表达和蛋白质合成的作用[J]. 生理学报 1999; 51 (5): .

Tan Shijin, Pan Jingyun, Zhan Chengyang, Zhu Xiaonan. Effect of angiotensin II on c-fos expression and protein synthesis in cultured rat myocardial cells. Acta Physiol Sin 1999; 51 (5): (in Chinese with English abstract).