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胃扩张刺激对大鼠大脑皮层及海马CCK mRNA表达的影响

唐明, 倪宏, 徐珞

青岛大学医学院生理教研室.山东,青岛 266021

摘要

在胃扩张机械性刺激作用下,皮层、海马CCK神经元内CCK mRNA表达增强,来自胃扩张刺激引起的神经信号可传入到中枢神经系统高级部位的皮层、海马等区,使脑细胞核内CCK基因转录水平发生变化。

关键词： 胆囊收缩素; 胃扩张; CCKmRNA; 大脑皮层; 海马

Changes in the mRNA concentration of preprocholecystokinin in rat cerebral cortex and hippocampus after gastric distension

Tang Ming, Ni Hong, Xu Luo

Department of Physiology,College of Medicine,Qingdao University.Qingdao 266021,Shandong

Abstract

Biosynthesis of CCK-containing neurons in cerebral cortex and hippocampus is accelerated by afferent signals from gastrointestinal system and may be involved in regulation of gastric motility and food intake.

Key words: Cholecystokinin;Gastric distension;CCK mRNA;Cerebral cortex;Hippocampus

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引用本文：

唐明, 倪宏, 徐珞. 胃扩张刺激对大鼠大脑皮层及海马CCK mRNA表达的影响[J]. 生理学报 1999; 51 (5): .

Tang Ming, Ni Hong, Xu Luo. Changes in the mRNA concentration of preprocholecystokinin in rat cerebral cortex and hippocampus after gastric distension. Acta Physiol Sin 1999; 51 (5): (in Chinese with English abstract).