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去甲肾上腺素介导低氧引起家兔颈动脉体神经电活动增加

庞雷, 苗智慧, 董力, 王燕凌

河北省医学科学院生理研究室.河北,石家庄 050021

摘要

在30只家兔颈动脉体-窦神经(CSN)标本上,记录了窦神经中39个对低氧反应敏感的化学感受性单位由去甲肾上腺素(NA)及其拮抗剂引起的反应。结果提示:(1)NA不是维持颈动脉体对缺氧敏感的化学感受纤维自发放电活动的主要因素,但给予NA能增加此类纤维自发放电的频率;(2)在低氧过程中,给予#alpha#_(2)受体拮抗剂育亨宾,可减弱这类纤维对缺氧反应的程度。

关键词： 颈动脉体; 单位放电; 低氧; 去甲肾上腺素; 育亨宾

Hypoxia-induced increase in nerve activity of rabbit carotid body mediated by noradrenaline

Pang Lei, Miao Zhihui, Dong Li, Wang Yanling

Department of Physiology,Hebei Academy of Medical Sciences.Shijiazhuang 050021,Hebei

Abstract

The responses of 39 hypoxia-sensitive units of chemoreceptive afferent in sinus nerve to noradrenaline (NA) and its antagonist were recorded in carotid body-sinus nerve preparations from 30 rabbits. The present results suggest that (1) NA is not mainly concerned with spontaneous discharges of chemoreceptor sensitive to hypoxia, but does elicit an increase in spontaneous discharges, and (2) the increase of chemosensory unit discharges produced by hypoxia can be inhibited by yohimbine.

Key words: Carotid body;Unit discharge;Hypoxia;Noradenaline;Yohimbine

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引用本文：

庞雷, 苗智慧, 董力, 王燕凌. 去甲肾上腺素介导低氧引起家兔颈动脉体神经电活动增加[J]. 生理学报 1999; 51 (4): .

Pang Lei, Miao Zhihui, Dong Li, Wang Yanling. Hypoxia-induced increase in nerve activity of rabbit carotid body mediated by noradrenaline. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).