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鲫鱼视网膜亮度型水平细胞上不同视锥信号的相互作用:实验及模型

梁培基

中科院上海生理研究所神经生物学开放实验室.上海 200031

摘要

实验表明,绿背景光的作用可以提高LHC的红光反应,这种增强作用与绿敏视锥的活动程度密切相关。模型分析表明,绿背景光的作用使谷氨酸介导的前馈性通路和GABA介导的反馈性通路活动同时得以增强。水平细胞对光反应的增强效应不能为外源性GABA所消除,而其程度为前馈性通路和反馈性通路活动增加的相对程度所决定。

关键词： 鲫鱼视网膜; 水平细胞; 相互作用; 模型分析

Interaction of cone signals on L-type horizontal cell in carp retina: Experiments and modeling

Liang Peiji

Key Laboratory of Neurobiology,Shanghai Institute of Physiology,Chinese Academy of Sciences.Shanghai 200031

Abstract

Intracellular recordings were made from the luminosity type cone driven horizontal cells (LHCs) in the isolated carp retina and model analysis was performed to investigate possible mechanisms underlying the interaction of different cone signals converging onto these cells. It was observed that a green background light enhanced the LHC^s red response, and such enhancement was closely related to the activation of green cones. Model analysis showed that the activity of both glutamate- and GABA-related pathways were potentiated during green background illumination. GABA application did not abolish the response enhancement. It is speculated that the extent of the LHC^s response enhancement may be determined by the balance of the increased activity between the feedforward and feedback pathways.

Key words: Isolated carp retina;Horizontal cell;Interaction;Model analysis

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引用本文：

梁培基. 鲫鱼视网膜亮度型水平细胞上不同视锥信号的相互作用:实验及模型[J]. 生理学报 1999; 51 (4): .

Liang Peiji. Interaction of cone signals on L-type horizontal cell in carp retina: Experiments and modeling. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).